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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
19.39
Human Site:
S361
Identified Species:
28.44
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S361
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S361
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
D430
S
M
P
L
G
A
R
D
L
I
S
K
L
L
R
Dog
Lupus familis
XP_853397
405
45606
S362
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
S352
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
Rat
Rattus norvegicus
P59241
397
44856
S354
E
G
A
R
D
L
I
S
R
L
L
K
H
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
L262
A
K
D
L
I
S
K
L
L
K
H
N
P
Y
Q
Chicken
Gallus gallus
XP_425725
409
46456
K361
A
I
S
R
V
E
F
K
Y
P
L
F
V
T
E
Frog
Xenopus laevis
Q91819
408
46443
V367
S
E
E
A
K
D
L
V
S
K
L
L
K
H
N
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
L279
V
S
E
G
A
R
D
L
I
S
K
L
L
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
R287
E
L
I
G
G
L
L
R
K
E
S
K
G
R
I
Honey Bee
Apis mellifera
XP_395732
327
37711
S286
Y
T
F
P
E
F
L
S
E
G
A
K
D
L
I
Nematode Worm
Caenorhab. elegans
O01427
305
34731
D264
I
G
R
L
L
V
V
D
P
K
A
R
C
T
L
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
R237
G
A
R
D
V
I
K
R
L
L
Q
H
N
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
S241
P
P
K
P
I
V
S
S
S
A
K
D
L
I
S
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
Q326
K
M
P
S
N
I
S
Q
D
A
Q
D
L
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
6.6
100
N.A.
93.3
93.3
N.A.
0
13.3
6.6
0
N.A.
20
13.3
6.6
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
93.3
N.A.
0
20
20
0
N.A.
33.3
26.6
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
7
32
7
7
7
0
0
0
13
13
0
0
0
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
0
7
7
32
7
7
13
7
0
0
13
7
0
0
% D
% Glu:
38
7
13
0
7
7
0
0
7
7
0
0
0
0
7
% E
% Phe:
0
0
7
0
0
7
7
0
0
0
0
7
0
0
0
% F
% Gly:
7
38
0
13
13
0
0
0
0
7
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
7
32
7
7
% H
% Ile:
7
7
7
0
13
13
32
0
7
7
0
0
0
13
13
% I
% Lys:
7
7
7
0
7
0
13
7
7
19
13
50
7
0
0
% K
% Leu:
0
7
0
19
7
38
19
13
19
38
44
13
25
13
13
% L
% Met:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
0
0
7
7
32
7
% N
% Pro:
7
7
13
13
0
0
0
0
7
7
0
0
7
7
19
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
13
0
0
0
7
% Q
% Arg:
0
0
13
38
0
7
7
13
32
0
0
7
0
13
7
% R
% Ser:
13
7
7
7
0
7
13
44
13
7
13
0
0
0
13
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
0
0
0
13
0
% T
% Val:
7
0
0
0
13
13
7
7
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _